怪物Monster)代表角色在游戏过程中将会遇到的各种敌对生物。

大多数怪物会通过接触或发射子弹的方式对角色造成伤害(少部分除外)。个别情况下,怪物会孵化出更小的怪物、分泌水迹,或者试图阻碍角色移动。有些较为普遍的怪物有它们的精英版本。精英怪物与它们的普通版形象相似,但有色彩或大小上的差别,且死亡后会生成基础的掉落。大多数BOSS们也有自己的变异版本。

到目前为止,共有182种怪物,其中35种是在DLC.png 胎衣中加入的,13种是在DLC+.png 胎衣†中加入的。

怪物列表

敌人图鉴
第1页第2页第3页第4页
Frowning Gaper.pngGaper.pngFlaming Gaper.pngGusher.pngMaggot.pngHive.pngDrowned Hive.pngCharger.pngHopper.gifTrite.gifBoil.pngGut.pngGuts.pngScarred Guts.pngKnight.pngSelfless Knight.png
Pacer.pngHorf.pngFly.pngPooter.pngDrowned Charger.pngGlobin.pngGazing Globin.pngDank Globin.pngSack.pngSpitty.pngBrain.pngLeaper.pngStone Grimace.pngVomit Grimace.pngPoky.pngSlide.png
Super Pooter.pngClotty.pngClot.pngI.Blob.pngBoom Fly.gifRed Boom Fly.gifDrowned Boom Fly.gifMaw.pngMr. Maw.pngMr. Maw.pngBaby.pngAngelic Baby.pngDople.pngEvil Twin.pngFlaming Hopper.pngLeech (Monster).png
Mulligan.pngMulligoon.pngMulliboom.pngAttack Fly.pngRed Maw.pngPsychic Maw.pngHost.pngRed Host.pngVis.pngDouble Vis.pngChubber.pngScarred Double Vis.pngKamikaze Leech.pngHoly Leech.pngLump.pngMemBrain.png
第5页第6页第7页第8页
Mama Guts.pngPara-Bite.pngScarred Para-Bite.pngFred.pngWalking Sack.pngButtlicker.pngHanger.pngSwarmer.pngCrazy Long Legs.pngSmall Crazy Long Legs.pngFatty.pngPale Fatty.pngCorn Dip.pngCorn Dip.pngWall Hugger.pngWizoob.png
Eye.pngBloodshot Eye (Monster).pngSucker.gifSpit.gifHeart.pngMask.pngBig Spider.pngEternal Fly.pngFlaming Fatty.pngFat Sack.pngBlubber.pngHalf Sack.pngSquirt.pngDank Squirt.pngCod Worm.pngRing Fly.png
Soul Sucker.pngEmpryo.pngMoter.pngSpider.pngStone Eye.pngTurret Grimace.pngCross Grimace.pngBrimstone Grimace.pngDeath's Head.pngDank Death's Head.pngMom's Hand.pngLevel 2 Fly.pngDinga.pngOob.pngBlack Maw.pngSkinny.png
Keeper.pngGurgle.pngWalking Boil.pngWalking Gut.pngMobile Host.pngNest.pngBaby Long Legs.pngSmall Baby Long Legs.pngLevel 2 Spider.pngSwinger.pngSwinger.pngDip.pngRotty.pngBony.pngHomunculus.pngTumor.png
第9页第10页第11页第12页
Camillo Jr..pngNerve Ending.gifNerve Ending 2.pngOne Tooth.pngFlesh Mobile Host.pngPsychic Horf.pngFull Fly.pngTicking Spider.pngBlack Globin.pngBlack Globin's Head.pngBlack Globin's Body.pngSwarm Fly.pngBlue Boil.pngGreed Gaper.pngMushroom (Monster).pngPoison Mind.png
Gaping Maw.pngBroken Gaping Maw.pngGurgling.pngSplasher.pngBegotten.pngNull.pngPsy Tumor.pngFloating Knight.pngMega Clotty.pngBone Knight.pngCyclopia.pngRed Ghost.pngStoney.pngBlister (Monster).pngThe Thing.pngMinistro.gif
Grub.pngWall Creep.pngRage Creep.pngBlind Creep.pngNightcrawler.pngDart Fly.pngConjoined Fatty.pngBlue Conjoined Fatty.pngFlesh Death's Head.pngMom's Dead Hand.pngDukie.pngUlcer.pngPortal.pngTar Boy.pngFistuloid.pngGush.png
Conjoined Spitty.pngRound Worm.pngTube Worm.pngRagling.pngFat Bat.pngImp.pngRoundy.pngBlack Bony.pngMeatball.pngCorn Mine.pngHush Fly.pngBlue Gaper.pngNO! Icon.pngNO! Icon.pngNO! Icon.pngNO! Icon.png
第13页第14页第15页第16页
Larry Jr..pngThe Hollow.pngC.H.A.D..pngCarrion Queen.pngMonstro II.pngGish.pngSuper Sloth.pngUltra Pride.png
Monstro.pngChub.pngGurdy.pngUltra Pride Baby.pngMom.pngSloth.pngLust.pngSuper Lust.png
第17页第18页第19页第20页
Wrath.pngSuper Wrath.pngGreed.pngSuper Greed.pngPride.pngSuper Pride.pngThe Frail.pngFamine.png
Gluttony.pngSuper Gluttony.pngEnvy.pngSuper Envy.pngPin.pngScolex.pngPestilence.pngWar.png
第21页第22页第23页第24页
Conquest.pngDeath.pngPeep.pngThe Bloat.pngFistula.pngTeratoma.pngIt Lives.pngGemini (Boss).png
The Duke of Flies.pngThe Husk.pngLoki.pngLokii.pngBlastocyst.pngMom's Heart.pngSteven (Boss).pngThe Blighted Ovum.png
第25页第26页第27页第28页
Gemini Baby.pngSteven Baby.pngKrampus.pngHeadless Horseman.pngMask of Infamy (Mask).pngMask of Infamy (Heart).pngThe Wretched.pngDaddy Long Legs.png
The Blighted Ovum Baby.pngThe Fallen.pngHeadless Horseman Head.pngSatan.pngGurdy Jr..pngWidow.pngTriachnid.pngIsaac (Boss).png
第29页第30页第31页第32页
Blue Baby (Boss).pngGurgling.pngLil' Haunt (Boss).pngDingle.pngThe Gate.pngMega Fatty.pngDark One.pngThe Adversary.png
Turdling.pngHaunt.pngDangle.pngMega Maw.pngThe Cage.pngMama Gurdy.pngPolycephalus.pngMr. Fred.png
第33页第34页第35页第36页
Uriel.pngFallen Uriel.pngThe Lamb.pngMega Satan's Head.pngBrownie.pngThe Forsaken.pngUltra Greed.pngUltra Greedier.png
Gabriel.pngFallen Gabriel.pngMega Satan 2's Head.pngThe Stain.pngLittle Horn (Boss).pngRag Man.pngHush.pngRag Mega.png
第37页
Sister Vis.pngBig Horn.png
Delirium.png
名称图片ID来源类型血量额外血量
死亡镰刀
Death Scythe
50px0.0.0重生怪物
皱眉凝视者
Frowning Gaper
Frowning Gaper.png10.0.0重生怪物100
凝视者
Gaper
Gaper.png10.1.0重生怪物100
火焰凝视者
Flaming Gaper
Flaming Gaper.png10.2.0胎衣怪物90
溅血者
Gusher
Gusher.png11.0.0重生怪物100
漫步者
Pacer
Pacer.png11.1.0重生怪物100
Horf
Horf
Horf.png12.0.0重生怪物100
苍蝇
Fly
Fly.png13.0.0重生怪物30
超级虹吸蝇
Super Pooter
Super Pooter.png14.1.0重生怪物80
虹吸蝇
Pooter
Pooter.png14.0.0重生怪物80
血液凝块
Clotty
Clotty.png15.0.0重生怪物150
焦油凝块
Clot
Clot.png15.1.0重生怪物150
难以名状
I.Blob
I.Blob.png15.2.0重生怪物150
炸弹穆里根
Mulliboom
Mulliboom.png16.2.0重生怪物130
穆里根
Mulligan
Mulligan.png16.0.0重生怪物130
独眼穆里根
Mulligoon
Mulligoon.png16.1.0重生怪物130
特殊隐藏房店主
Special Secret Room Keeper
Special Secret Room Keeper.png17.4.0胎衣怪物
商店店主
Shopkeeper
Shopkeeper.png17.0.0重生怪物
隐藏房店主
Secret Room Keeper
Secret Room Keeper.png17.1.0重生怪物
错误房店主
Error Room Keeper
Error Room Keeper.gif17.2.0重生怪物
特殊商店店主
Special Shopkeeper
Special Shopkeeper.png17.3.0胎衣怪物
攻击苍蝇
Attack Fly
Attack Fly.png18.0.0重生怪物50

Maggot
Maggot.png21.0.0重生怪物150
苍蝇巢
Hive
Hive.png22.0.0重生怪物200
水淹苍蝇巢
Drowned Hive
Drowned Hive.png22.1.0胎衣怪物180
水淹冲锋怪
Drowned Charger
Drowned Charger.png23.1.0胎衣怪物220
冲锋怪
Charger
Charger.png23.0.0重生怪物200
我的影子
My Shadow
50px23.0.1胎衣怪物200
球蛋白
Globin
Globin.png24.0.0重生怪物330
凝视球蛋白
Gazing Globin
Gazing Globin.png24.1.0重生怪物330
阴冷球蛋白
Dank Globin
Dank Globin.png24.2.0胎衣怪物330
炸弹苍蝇
Boom Fly
Boom Fly.gif25.0.0重生怪物200
红色炸弹苍蝇
Red Boom Fly
Red Boom Fly.gif25.1.0重生怪物200
水淹炸弹苍蝇
Drowned Boom Fly
Drowned Boom Fly.gif25.2.0胎衣怪物200
红色大嘴
Red Maw
Red Maw.png26.1.0重生怪物200
超能大嘴
Psychic Maw
Psychic Maw.png26.2.0重生怪物200
大嘴
Maw
Maw.png26.0.0重生怪物200
宿主
Host
Host.png27.0.0重生怪物150
红色宿主
Red Host
Red Host.png27.1.0重生怪物150
跳虫
Hopper
Hopper.gif29.0.0重生怪物100
六足蜘蛛
Trite
Trite.gif29.1.0重生怪物100
肠子
Gut
Gut.png30.1.0重生怪物200
蜘蛛袋
Sack
Sack.png30.2.0重生怪物200

Boil
Boil.png30.0.0重生怪物200
吐痰蛆
Spitty
Spitty.png31.0.0重生怪物100
脑子
Brain
Brain.png32.0.0重生怪物200
跳跃者
Leaper
Leaper.png34.0.0重生怪物250
大嘴先生的头
Mr. Maw Head
50px35.1.0重生怪物0
大嘴先生的身体
Mr. Maw Body
50px35.0.0重生怪物0
宝宝
Baby
Baby.png38.0.0重生怪物250
天使宝宝
Angelic Baby
Angelic Baby.png38.1.0重生怪物250
疤痕二重力量
Scarred Double Vis
Scarred Double Vis.png39.3.0胎衣怪物220
力量
Vis
Vis.png39.0.0重生怪物250
二重力量
Double Vis
Double Vis.png39.1.0重生怪物250
养蛆者
Chubber
Chubber.png39.2.0重生怪物250
养蛆者弹射物
Chubber Projectile
50px39.22.0重生怪物
内脏
Guts
Guts.png40.0.0重生怪物250
疤痕内脏
Scarred Guts
Scarrrd Guts.png40.1.0胎衣怪物280
无私骑士
Selfless Knight
Selfless Knight.png41.1.0重生怪物200
骑士
Knight
Knight.png41.0.0重生怪物200
石鬼面
Stone Grimace
Stone Grimace.png42.0.0重生怪物200
呕吐鬼面
Vomit Grimace
Vomit Grimace.png42.1.0重生怪物200
Poky
Poky
Poky.png44.0.0重生怪物
滑块
Slide
Slide.png44.1.0重生怪物
二重身
Dople
Dople.png53.0.0重生怪物200
邪恶双子
Evil Twin
Evil Twin.png53.1.0重生怪物200
燃烧跳虫
Flaming Hopper
Flaming Hopper.png54.0.0重生怪物200
水蛭
Leech
Leech (Monster).png55.0.0重生怪物250
神风水蛭
Kamikaze Leech
Kamikaze Leech.png55.1.0重生怪物250
神圣水蛭
Holy Leech
Holy Leech.png55.2.0重生怪物250
肿块
Lump
Lump.png56.0.0重生怪物300
大脑
MemBrain
MemBrain.png57.0.0重生怪物620
内脏妈妈
Mama Guts
Mama Guts.png57.1.0重生怪物620
咬咬寄生虫
Para-Bite
Para-Bite.png58.0.0重生怪物350
疤痕咬咬寄生虫
Scarred Para-Bite
Scarred Para-Bite.png58.1.0胎衣怪物350
弗雷德
Fred
Fred.png59.0.0重生怪物200
眼睛
Eye
Eye.png60.0.0重生怪物200
血泪之眼
Bloodshot Eye
Bloodshot Eye (Monster).png60.1.0重生怪物200
灵魂吸收蝇
Soul Sucker
Soul Sucker.png61.2.0胎衣†怪物180
吸收蝇
Sucker
Sucker.gif61.0.0重生怪物100
吐痰蝇
Spit
Spit.gif61.1.0重生怪物100
肿胀的眼睛
Bloat Eye
Bloat Eye.png68.11.0重生怪物
窥视的眼睛
Peep Eye
Peep Eye.png68.10.0重生怪物
胚胎
Embryo
Embryo.png77.0.0重生怪物120
妈妈的内脏
Moms Guts
50px78.10.0重生怪物
枯萎卵宝宝
The Blighted Ovum Baby
The Blighted Ovum Baby.png79.12.0重生怪物1400
灰尘苍蝇
Moter
Moter.png80.0.0重生怪物100
蜘蛛
Spider
Spider.png85.0.0重生怪物6.50
店主
Keeper
Keeper.png86.0.0重生怪物360
流泪凝视者
Gurgle
Gurgle.png87.0.0重生怪物400
心脏
Heart
Heart.png92.0.0重生怪物400
面具
Mask
Mask.png93.0.0重生怪物
大蜘蛛
Big Spider
Big Spider.png94.0.0重生怪物200
永恒苍蝇
Eternal Fly
Eternal Fly.png96.0.0重生怪物
石眼
Stone Eye
Stone Eye.png201.0.0重生怪物
蜘蛛巢
Nest
Nest.png205.0.0重生怪物200
神经末梢
Nerve Ending
Nerve Ending.gif231.0.0重生怪物200
神经末梢2
Nerve Ending 2
Nerve Ending 2.png231.1.0胎衣†怪物200
空值
Null
Null.png252.0.0重生怪物300
溃疡
Ulcer
Ulcer.png289.0.0胎衣怪物100
肉球
Meatball
Meatball.png290.0.0胎衣怪物150
Hush苍蝇
Hush Fly
Hush Fly.png296.0.0胎衣怪物100
蓝色凝视者
Blue Gaper
Blue Gaper.png297.0.0胎衣怪物300
蓝色疖
Blue Boil
Blue Boil.png298.0.0胎衣怪物200
贪婪凝视者
Greed Gaper
Greed Gaper.png299.0.0胎衣怪物90
蘑菇
Mushroom
Mushroom (Monster).png300.0.0胎衣†怪物230
剧毒意志
Poison Mind
Poison Mind.png301.0.0胎衣†怪物200
水疱
Blister
Blister (Monster).png303.0.0胎衣†怪物540
爬墙魔物
The Thing
The Thing.png304.0.0胎衣†怪物150
迷你怪蛋
Ministro
Ministro.gif305.0.0胎衣†怪物90
传送门
Portal
Portal.png306.0.0胎衣†怪物95
小瘘管
Fistuloid
Fistuloid.png308.0.0胎衣†怪物300
怪物 描述
Black Fly

Fly.png

Tiny black fly with neutral AI. Does not hurt Isaac upon touch.
Attack Fly

Attack Fly.png

Red fly that follows Isaac and deals touch damage.
Ring Fly

Ring Fly.png

Gathers with any other Ring Flies in the room. These flies orbit around themselves, while following Isaac.
DLC.png Dart Fly

Dart Fly.png

Flies towards Isaac and attempts to mimic his movements. Deals contact damage.
DLC.png Swarm Fly

Swarm Fly.png

Follows Isaac in large groups and deals contact damage.
DLC.png Hush Fly

Hush Fly.png

Gathers with other Hush Flies and flies towards Isaac in certain patterns. Can also orbit Hush.
Moter

Moter.png

Follows Isaac, similar to Attack Flies. Splits into 2 Attack Flies upon death.
Eternal Fly

Eternal Fly.png

Invulnerable fly that circles corny poop and various monsters. Turns into a vulnerable Attack Fly after the object or monster it circles is destroyed.
Pooter

Pooter.png

Slow-moving fly that occasionally fires single blood shots at Isaac. Does not deal touch damage.
Super Pooter

Super Pooter.png

An alternate version of the Pooter that fires 2 shots in a V-formation and does not deal touch damage.
Boom Fly

Boom Fly.gif

Flies around the room diagonally, dealing touch damage and exploding upon death.
Red Boom Fly

Red Boom Fly.gif

Flies around the room diagonally, dealing touch damage and exploding into 6 blood shots upon death.
DLC.png Drowned Boom Fly

Drowned Boom Fly.gif

Flies around the room diagonally, dealing touch damage. Upon death, explodes, fires four blood shots in the cardinal directions, and spawns a Drowned Charger.
Level 2 Fly

Level 2 Fly.png

Flies toward Isaac erratically, dealing touch damage.
Full Fly

Full Fly.png

Flies toward Isaac erratically, dealing touch damage. Splits into 6 directional shots upon death.
Sucker

Sucker.gif

Flies slowly towards Isaac, exploding into 4 shots in the cardinal directions upon death.
Spit

Spit.gif

Flies slowly towards Isaac, firing an Ipecac shot upon death.
DLC+.png Soul Sucker

Soul Sucker.png

Flies slowly towards Isaac, firing four Brimstone beams in the cardinal directions upon death.
Dip

Fly.png

Slowly dashes in random directions, dealing contact damage.
DLC.png Corn Dip

Corn Dip.png

Quickly dashes in random directions, dealing contact damage.
Squirt

Squirt.png

Dashes towards the player and deals contact damage. Spawns 2 Dips upon death.
DLC.png Dank Squirt

Dank Squirt.png

Dashes towards the player and deals contact damage. Spawns 2 Clots upon death.
Dinga

Dinga.png

Spawns Dips and shoots brown shots in 8 directions. Spawns 2 Squirts on death.
Spider

Spider.png

Erratically moves towards Isaac and deals touch damage.
Big Spider

Big Spider.png

Erratically moves towards Isaac and deals touch damage. Splits into two Spiders upon death.
Trite

Trite.gif

Quickly leaps towards Isaac and deals touch damage.
Ragling

Ragling.png

Quickly leaps towards Isaac and deals touch damage. Randomly shoots two purple shots that orbit around it.
DLC+.png Blister

Blister (Monster).png

Slowly hops towards Isaac, occasionally spawning black smoke balls. Spawns a Sack upon death.
Level 2 Spider

Level 2 Spider.png

Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances.
Ticking Spider

Ticking Spider.png

Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances. Explodes upon death.
Baby Long Legs

Baby Long Legs.png

Runs away from Isaac and frequently spawns Spiders.
Small Baby Long Legs

Small Baby Long Legs.png

Runs away from Isaac and occasionally spawns Sacks.
Crazy Long Legs

Crazy Long Legs.png

Chases Isaac, dealing touch damage. Occasionally stops to spit blood shots in 8 directions.
Small Crazy Long Legs

Small Crazy Long Legs.png

Chases Isaac, dealing touch damage. Occasionally stops to spit blood shots diagonally in 4 directions.
Wall Creep

Wall Creep.png

Crawls along walls to try to line up with Isaac and shoots three blood shots in a line.
Blind Creep

Blind Creep.png

Randomly crawls along walls and shoots three spread blood shots.
Rage Creep

Rage Creep.png

Crawls along walls to try to line up with Isaac and shoots a Brimstone laser.
DLC+.png The Thing

The Thing.png

Crawls along a wall and attempts to line up with Isaac, then spits a line of damaging red creep.
Boil

Boil.png

Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires multiple short-ranged blood projectiles in random directions when fully swollen.
Gut

Gut.png

Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires Ipecac shots in random directions when fully swollen.
Sack

Sack.png

Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Occasionally spawns Spiders when fully swollen.
DLC+.png Gush

Gush.png

Stationary, harmless enemy that continually creates slowing black creep.
DLC.png Blue Boil

Blue Boil.png

Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.
Walking Boil

Walking Boil.png

Does not shrink or regenerate. Walks around aimlessly and fires multiple short-ranged blood projectiles in random directions.
Walking Gut

Walking Gut.png

Does not shrink or regenerate. Walks around aimlessly and fires Ipecac shots in random directions.
Walking Sack

Walking Sack.png

Does not shrink or regenerate. Walks around aimlessly and occasionally spawns Spiders.
Round Worm

Round Worm.png

Pops out of the ground in random locations and spits a blood shot at Isaac if he is in sight.
Nightcrawler

Nightcrawler.png

Pops out of the ground in random locations and fires four short-range shots that spiral outwards if Isaac is in sight.
DLC+.png Tube Worm

Tube Worm.png

Pops out of the ground in random locations and fires a long-range spray of arcing shots.
DLC.png Roundy

Roundy.png

Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.
DLC.png Ulcer

Ulcer.png

Pops out of the ground in random locations and spits a blood shot at Isaac or spawns a Dart Fly if Isaac is in sight.
Mulligan

Mulligan.png

Walks around the room, avoiding Isaac. Upon death, spawns several flies, which can be Black Flies, Attack Flies, or Pooters. Can suicide to explode and launch projectiles in the four ordinal directions while still releasing flies.
Mulligoon

Mulligoon.png

Walks around the room, avoiding Isaac. Upon death, spawns a Troll Bomb and fires four shots in the ordinal directions. Can suicide to explode, spawn a Troll bomb, and launch projectiles in eight directions.
Mulliboom

Mulliboom.png

Chases Isaac and explodes upon death or upon touching Isaac. The explosion deals a half-heart of damage instead of the regular full heart.
Hive

Hive.png

Walks around the room, avoiding Isaac while spawning Attack Flies. Spawns a large number of flies upon death, which can be Black Flies, Attack Flies, Pooters, or Fat Flies.
Nest

Nest.png

Walks around the room, avoiding Isaac while spawning Spiders. Spawns a Big Spider or a Trite upon death.
DLC.png Drowned Hive

Drowned Hive.png

Walks around the room, avoiding Isaac while spawning Drowned Chargers. Spawns a Drowned Charger upon death.
Swarmer

Swarmer.png

Slowly floats around the room, spawning several Pooters upon taking damage. Spawns a Boom Fly upon death.
DLC.png Dukie

Dukie.png

Flies around the room diagonally, occasionally spitting out a Dart Fly.
Hopper

Hopper.gif

Slowly hops around the room, dealing touch damage. Can turn into a Flaming Hopper by jumping into fire.
Flaming Hopper

Flaming Hopper.png

Quickly hops around the room, dealing touch damage. Covers a larger distance than the regular Hopper.
Leaper

Leaper.png

Hops around the room, dealing touch damage. Occasionally jumps high into the air, dropping down onto Isaac's position while firing 4 blood shots in the cardinal directions.
DLC+.png Ministro

Ministro.gif

Hops towards Isaac, occasionally spitting out a cluster of disorganized shots.
Pacer

Pacer.png

Walks aimlessly around the room.
Gusher

Gusher.png

Walks aimlessly around the room, occasionally firing short-ranged blood shots.
DLC.png Black Globin's Body

Black Globin's Body.png

Walks aimlessly around the room, occasionally spawning spiders.
Gaper

Gaper.png

Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
Frowning Gaper

Frowning Gaper.png

Walks towards Isaac, dealing contact damage. Upon getting near Isaac, it will open its eyes and pursue Isaac faster. Usually turns into a Pacer or a Gusher upon death.
DLC.png Flaming Gaper

Flaming Gaper.png

Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
DLC.png Cyclopia

Cyclopia.png

Walks towards Isaac, dealing contact damage and leaving behind a trail of damaging red creep. Occasionally shoots a blood shot towards Isaac.
DLC.png Blue Gaper

Blue Gaper.png

Walks towards Isaac, dealing contact damage. Has triple the health of a normal Gaper.
DLC.png Greed Gaper

Greed Gaper.png

Walks towards Isaac, dealing contact damage.
Gurgle

Gurgle.png

Walks towards Isaac, firing Ipecac shots at him. Can turn into a Splasher upon death.
Splasher

Splasher.png

Walks aimlessly around the room, firing Ipecac shots in random directions.
Skinny

Skinny.png

Slowly walks towards Isaac, leaving short-lasting red creep behind itself.
Rotty

Rotty.png

Slowly walks towards Isaac, leaving short-lasting red creep behind itself. Spawns a Bony or two Attack Flies upon death.
Mr. Maw

Mr Maw.png

Walks towards Isaac and attacks by launching its head towards Isaac. Turns into a Maw or Pacer upon death depending on the killed body segment.
Horf

Horf.png

Stationary enemy that fires medium ranged blood shots at Isaac.
Psychic Horf

Psychic Horf.png

Stationary enemy that fires homing shots at Isaac.
Maw

Maw.png

Slowly floats towards Isaac, firing blood shots.
Red Maw

Red Maw.png

Floats towards Isaac and explodes into 4 blood shots in the cardinal directions upon death.
Psychic Maw

Psychic Maw.png

Slowly floats towards Isaac, firing homing shots. Spawns with an Eternal Fly orbiting around it.
Bony

Bony.png

Wanders around the room and throws a bone at Isaac when he is in sight.
DLC.png Black Bony

Black Bony.png

Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.
Death's Head

Death's Head.png

Invulnerable enemy that moves diagonally around the room, dealing contact damage. Dies when the room is cleared.
DLC.png Dank Death's Head

Dank Death's Head.png

Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.
DLC.png Flesh Death's Head

Flesh Death's Head.png

Moves diagonally around the room, dealing contact damage. Explodes into 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.
One Tooth

One Tooth.png

Follows Isaac and periodically dashes towards Isaac when it gets close. Deals contact damage.
DLC.png Fat Bat

Fat Bat.png

Slowly flies towards Isaac. Shoots when Isaac aligns diagonally with it and will actively try to avoid Isaac's shots.
Lil' Haunt

Lil' Haunt.png

Follows Isaac erratically and occasionally shoots blood shots toward Isaac's destination, predicting his movements.
Wizoob

Wizoob.png

Disappears, then appears near Isaac and spits a cluster of spectral tears at him.
DLC.png Red Ghost

Red Ghost.png

Disappears, then reappears near Isaac and fires a brimstone laser.
Fatty

Fatty.png

Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away.
DLC.png Flaming Fatty

Flaming Fatty.png

Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away. Has a chance to leave behind a damaging flame upon death.
DLC+.png Stoney

Stoney.png

Chases Isaac and blocks tears, but does not deal contact damage. Invulnerable; dies when the room is cleared.
DLC.png Conjoined Fatty

Conjoined Fatty.png

Slowly walks towards Isaac. Occasionally spits a line of damaging green creep towards Isaac. Turns into a regular Fatty upon death.
DLC.png Blue Conjoined Fatty

Blue Conjoined Fatty.png

Slowly walks towards Isaac and occasionally spits a homing Ipecac shot at Isaac.
Pale Fatty

Pale Fatty.png

Slowly walks towards Isaac. Occasionally farts and shoots blood shots in 6 directions. Can turn into a Blubber upon death.
Fat Sack

Fat Sack.png

Slowly walks towards Isaac. Occasionally leaps off-screen and attempts to land on Isaac, leaving a puddle of creep and shooting blood shots in 6 directions where it lands. Can turn into a Blubber upon death.
Blubber

Blubber.png

Walks around aimlessly and randomly spews blood around itself. Can turn into a Half Sack when killed.
Half Sack

Half Sack.png

Wanders around aimlessly and leaves a trail of red creep.
Globin

Globin.png

Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
Gazing Globin

Gazing Globin.png

Quickly chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
DLC.png Dank Globin

Dank Globin.png

Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a spider, and leaves a puddle of slowing black creep. Will regenerate after a short period of time if not killed quickly.
DLC.png Black Globin

Black Globin.png

Chases Isaac, dealing a full heart of contact damage and spawning spiders. Upon taking enough damage, it separates into a head and body. The head slides towards Isaac, leaving a trail of damaging red creep. The body wanders around aimlessly, occasionally spawning spiders.
Knight

Knight.png

Moves erratically around the room and charges toward Isaac when in line of sight. Can only be damaged from behind.
Selfless Knight

Selfless Knight.png

Moves erratically around the room and charges toward Isaac very quickly when in line of sight. Can only be damaged from behind.
Floating Knight

Floating Knight.png

Behaves like the Knight but can fly over all obstacles.
DLC.png Bone Knight

Bone Knight.png

Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a trail of damaging red creep. Can only be damaged from behind.
Mask + Heart

Mask Heart.png

The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the cardinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask.
Clotty

Clotty.png

Randomly wanders around the room, firing 4 blood shots in the cardinal directions.
Clot

Clot.png

Randomly wanders around the room, firing 4 tar shots in the ordinal directions.
I. Blob

I.Blob.png

Randomly wanders around the room, firing 8 shots in all directions.
DLC.png Mega Clotty

Mega Clotty.png

Slowly moves around the room, occasionally hopping and firing 6 blood shots in all directions. Splits into two Clotties upon death.
Mom's Hand

Mom's Hand.png

Falls from the ceiling. If it lands on Isaac, it deals damage and teleports the player back to the spawn room of the floor. Entering a room containing Mom's Hand will warn the player with Mom's laugh.
DLC.png Mom's Dead Hand

Mom's Dead Hand.png

Falls from the ceiling. If it lands on Isaac, it deals damage and teleports the player back to the spawn room of the floor. If it doesn't land on Isaac, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn the player with Mom's laugh.
Maggot

Maggot.png

Aimlessly moves around the room, dealing contact damage.
Charger

Charger.png

Slowly moves around the room, charging at Isaac when he gets in its line of sight.
DLC.png Drowned Charger

Drowned Charger.png

Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.
Spitty

Spitty.png

Slowly moves around the room, occasionally firing a single blood shot forwards.
Conjoined Spitty

Conjoined Spitty.png

Slowly moves around the room, occasionally firing blood shots from both ends of its body.
Tumor

Tumor.png

Moves around the room diagonally, occasionally firing 6 shots. Fires more often upon getting damaged.
Psy Tumor

Psy Tumor.png

Moves around the room diagonally, occasionally firing 6 homing shots. Fires more often upon getting damaged.
Camillo Jr.

Camillo Jr.png

Moves around the room diagonally, occasionally firing Technology lasers towards Isaac. Fires more often upon getting damaged.
Brain

Brain.png

Slowly crawls around the room, leaving a trail of red creep.
DLC+.png Poison Mind

Poison Mind.png

Slowly crawls around the room diagonally, leaving a trail of green creep.
MemBrain

MemBrain.png

Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Brains upon death.
Guts

Guts.png

Attaches itself to a wall or obstacle and rolls around it.
DLC.png Scarred Guts

Scarred Guts.png

Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging red creep.
Mama Guts

Mama Guts.png

Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Guts upon death.
Buttlicker

Buttlicker.png

Attaches itself to other Buttlickers and erratically moves around the room, similar to Larry Jr..
Grub

Grub.png

Erratically moves around the room like Larry Jr. and charges at Isaac when he gets within its line of sight. Spawns random types of maggots upon death, one for each of its segments.
Para-Bite

Para-Bite.png

Moves towards Isaac, dealing contact damage. Can burrow underground and reappear elsewhere.
DLC.png Scarred Para-Bite

Scarred Para-Bite.png

Moves towards Isaac, dealing contact damage and firing short-range blood shots. Can burrow underground and reappear elsewhere.
Cod Worm

Cod Worm.png

Stationary enemy that hides in a shell and spews blood if shot at. Only vulnerable when it pops its head out.
Fred

Fred.png

Hops out of the ground and burrows elsewhere, firing 4 blood shots in the ordinal directions. Occasionally fires red Ipecac shots at Isaac.
Lump

Lump.png

Fires 3 spread blood shots at Isaac when he gets in its line of sight. Will burrow underground and reappear elsewhere after firing.
DLC+.png Tar Boy

Tar Boy.png

Pops out of the ground in random locations and fires a short-ranged spray of shots that leave behind slowing black creep. If Isaac stands in the creep, the Tar Boy can fire shots straight upwards out of the creep underneath Isaac.
Leech

Leech (Monster).png

Quickly charges towards Isaac when he gets in its line of sight.
Kamikaze Leech

Kamikaze Leech.png

Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death.
Holy Leech

Holy Leech.png

Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death. Spawns with an Eternal Fly circling it.
Host

Host.png

Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will fire 3 blood shots and lower its head again.
Red Host

Red Host.png

Stationary enemy that can be damaged even when its head is lowered. Fire 5 spread blood shots when it raises its head.
Mobile Host

Mobile Host.png

Acts like the Host, but follows Isaac and deals contact damage.
Flesh Mobile Host

Flesh Mobile Host.png

Acts like the Red Host, but follows Isaac and deals contact damage.
DLC+.png Mushroom

Mushroom (Monster).png

Stationary enemy that occasionally pops up and fires four shots in the cardinal or diagonal directions. Takes less damage while its head is down.
DLC.png Meatball

Meatball.png

Slides around the room, occasionally stopping to spew a fountain of short-range blood shots in all directions or to spit a line of damaging red creep. Spawns a Host upon death.
Nerve Ending

Nerve Ending.gif

Static enemy which acts as a meat shield.
DLC+.png Nerve Ending 2

Nerve Ending 2.png

Static enemy which whips at Isaac if he gets too close.
Vis

Vis.png

Charges and fires a Brimstone laser when Isaac gets in its line of sight.
Double Vis

Double Vis.png

Charges and fires a Brimstone laser which fires from both sides when Isaac gets in its line of sight.
DLC.png Scarred Double Vis

Scarred Double Vis.png

Charges and fires a Brimstone laser which fires from all four sides when Isaac gets in its line of sight.
Chubber

Chubber.png

Fires a Charger that deals one heart of damage when Isaac gets in its line of sight. The Charger is invulnerable, blocks Isaac's tears, and has limited range.
Wall Hugger

Movingspikeblock.png

Moves around the room like Guts, damaging Isaac by contact. Cannot be destroyed.
Slide

Bluespikeblock.png

Quickly slides towards Isaac when he gets in its line of sight, then moves slowly back to its original position. Cannot be destroyed.
Poky

Poky.png

Slides around the room aimlessly, damaging Isaac by contact. Disappears when the room is cleared.
Eye

Eye.png

Slowly turns towards Isaac and fires a laser at Isaac if he stands still or is too slow.
Bloodshot Eye

Bloodshot Eye (Monster).png

Slowly turns towards Isaac and fires a Brimstone beam at Isaac if he stands still or is too slow.
Dople

Dople.png

Mirrors Isaac's movements and fires blood shots at the same time as Isaac. Can be damaged by spikes.
Evil Twin

Evil Twin.png

Mirrors Isaac's movements and fires three spread blood shots at the same time as Isaac. Can fly over obstacles.
Embryo

Embryo.png

Aimlessly hops around the room, dealing contact damage.
Baby

Baby.png

Slowly floats towards Isaac and fires blood shots. Occasionally teleports and reappears elsewhere.
Angelic Baby

Angelic Baby.png

Slowly floats towards Isaac and fires three spread shots. Occasionally teleports and reappears elsewhere.
DLC.png Imp

Imp.png

Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards Isaac. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Homunculus

Homunculus.png

Starts attached to the wall. After a while, it detaches, shooting 6 blood shots and chasing Isaac. If it dies while still attached to the wall, it leaves a puddle of creep.
Begotten

Begotten.png

Starts attached to the wall. After a while, it detaches, turning the room dark and chasing Isaac. Phases in and out of visibility.
Null

Null.png

Act like faster Frowning Gapers. When Isaac gets near, they phase in and out of visibility and pursue Isaac faster.
Swinger

Swinger.png

Slowly moves towards Isaac as its head swings around its base. Upon death, spawns a Maw or a Globin depending on which part is killed.
Keeper

Keeper.png

Hops around the room, firing 2 blood shots in a V formation at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3.
Hanger

Hanger.png

Floats around the room, firing 3 spread blood shots at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3. Spawns with an eternal fly circling around it.
DLC+.png Fistuloid

Fistuloid.png

Flies towards Isaac in an erratic waving motion, periodically firing a blood shot towards Isaac that also knocks itself back. Upon death, fires a worm that flies off screen.
Stone Grimace

Stone Grimace.png

Stationary and invulnerable monster that occasionally fires blood shots at Isaac. Stops firing when room is cleared.
Vomit Grimace

Vomit Grimace.png

Stationary and invulnerable monster that occasionally fires an Ipecac shot at Isaac. Stops firing when room is cleared.
Gaping Maw

Gaping Maw.png

Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles.
Broken Gaping Maw

Broken Gaping Maw.png

Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles.
Turret Grimace

Turret Grimace.png

Stationary and invulnerable monster that continuously fires shots in a single direction.
DLC+.png Cross Grimace

Cross Grimace.png

Stationary and invulnerable monster that continuously fires shots in four directions.
Stone Eye

Stone Eye.png

Stationary and invulnerable monster that constantly rotates and fires a flickering Technology laser. Stops firing when the room is cleared.
Brimstone Grimace

Brimstone Grimace.png

Stationary and invulnerable monster that fires Brimstone beams in a specific direction.
Oob

Oob.png

When Isaac lines up with it horizontally, it charges across the room once. When Isaac is not horizontal to it, it spawns Brains.
Black Maw

Black Maw.png

When Isaac lines up with it horizontally, it charges in his direction and then doubles back, charging back to its original position. When Isaac is not horizontal to it, it spawns Kamikaze Leeches. Explodes when it dies.
DLC+.png Portal

Portal.png

Continually spawns enemies from the current floor until it is killed.

精英怪物(Champions)

Ed's basic example of potential color variations.

有些怪物有与它们在色彩及大小上略有差别的精英版本。从精英怪物的颜色可以看出它们变异的特殊能力。在普通模式中,精英怪物被杀死通常会生成掉落(根据精英怪物的颜色)。然而在困难模式中,精英怪物死亡后大概率不生成掉落。所有的精英怪物都会造成接触伤害,即便他们的普通版本没有接触伤害。大多数精英怪物会造成整颗心的伤害(无论在哪个章节)以及拥有双倍的血量。攻略困难模式,拥有冠军腰带紫色的心,或解锁成就一切都好可怕!!!后,都会增加精英怪物的出现概率。精英怪物通常比普通怪物更危险。

精英怪物的识别方法见下表:

精英类型

ID 外观 效果 掉落
0 红色 2.5倍血量。
1 黄色 增加移速及射速。 电池
2 绿色 走过的地方留下绿色水迹 药丸
3 橙色 击中角色掉落硬币(类似于贪婪)。 硬币
4 深蓝色 无。 3只蓝苍蝇
5 深绿色 死亡后爆炸。 炸弹
6 纯白色 房间内存在其他敌人时无敌。 永恒之心
7 灰色 2/3倍血量,但造成双倍伤害。 钥匙
8 透明白色 拥有幽灵眼泪,眼泪可以穿过障碍物 金宝箱
9 黑色(略带绿) 会隐身,类似于Null 红宝箱
10 粉色 定期射出短射程的血泪,类似于Gushers
11 紫色 将角色吸向自己,类似于Gaping Maw 随机饰品
12 深红色 死亡后变为一个肉块,如果没及时清理则会再生,类似于Globin 双红心
13 浅蓝色 死亡后释放8方向血泪。 半红心
14 DLC.png 保护色 拥有保护色可融入环境不易识别,只在受伤后短暂可见。 符文
15 DLC.png 闪烁绿色 死亡后生成两个普通版本的自己。 两个普通版自己
16 DLC.png 闪烁灰色 闪烁时排斥角色的子弹。
17 DLC.png 浅白色 拥有1-2个永恒苍蝇环绕。死亡后生成1只红苍蝇 红苍蝇
18 DLC.png 小体型 血量大幅降低,移速增加,音效变细。体型变小使其更难被击中。 变小药丸
19 DLC.png 大体型 血量大幅增加,移速降低,音效变粗。体型变大使其更易被击中。造成两颗心的伤害! 变大药丸
20 DLC+.png 闪烁红色 会高速给房间内的其他敌人回复血量。
21 DLC+.png 闪烁 每次攻击产生一个红苍蝇 5只蓝苍蝇
22 DLC+.png 皇冠Crown Effect.gif 血量大幅增加。房间内所有非精英怪物都会变异为它们的黄色精英版本,直到自己死亡。 2个随机掉落
23 DLC+.png 头骨 死亡时激活死灵书的效果。 死灵书效果

怪物变种(Monster Variants)

这些变种有几率取代房间内的普通怪物被生成。

重生

基础怪物 可能的替换
Mulligan.png Mulligoon.pngMulliboom.png
Hopper.gif Trite.gif
Stone Grimace.png Vomit Grimace.png
Dople.png Evil Twin.png
Eye.png Bloodshot Eye (Monster).png
Leech (Monster).png Kamikaze Leech.pngHoly Leech.png
Maw.png Red Maw.pngPsychic Maw.png
Host.png Red Host.png
Vis.png Double Vis.pngChubber.png
Boom Fly.gif Red Boom Fly.gif
Pooter.png Fat Fly.png
Pacer.png Gusher.png
Knight.png Selfless Knight.png
Clotty.pngClot.png I.Blob.png
MemBrain.png Mama Guts.png
Gaper.png Frowning Gaper.png
Globin.png Gazing Globin.png
Baby.png Angelic Baby.png
Boil.pngSack.png Gut.png
Sucker.gif Spit.gif

胎衣

基础怪物 可能的替换
Gaper.png Flaming Gaper.png
Fatty.png Flaming Fatty.png
Hive.png Drowned Hive.png
Charger.png Drowned Charger.png
Squirt.png Dank Squirt.png
Death's Head.png Dank Death's Head.pngFlesh Death's Head.png
Globin.png Dank Globin.png
Guts.png Scarred Guts.png
Para-Bite.png Scarred Para-Bite.png
Double Vis.png Scarred Double Vis.png

胎衣†

基础怪物 可能的替换
Keeper.pngTicking Spider.png Blister (Monster).png
Host.pngRed Host.png Mushroom (Monster).png
Hopper.gifTrite.gif Ministro.gif
Nerve Ending.gif Nerve Ending 2.png
Brain.png Poison Mind.png
Pale Fatty.png Stoney.png
Wall Creep.pngBlind Creep.pngRage Creep.png The Thing.png
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