怪物Monster)代表角色在游戏过程中将会遇到的各种敌对生物。

大多数怪物会通过接触或发射子弹的方式对角色造成伤害(少部分除外)。个别情况下,怪物会孵化出更小的怪物、分泌水迹,或者试图阻碍角色移动。有些较为普遍的怪物有它们的精英版本。精英怪物与它们的普通版形象相似,但有色彩或大小上的差别,且死亡后会生成基础的掉落。大多数BOSS们也有自己的变异版本。

到目前为止,共有182种怪物,其中35种是在DLC.png 胎衣中加入的,13种是在DLC+.png 胎衣†中加入的。

怪物列表(Monster List)

敌人图鉴
第1页 第2页 第3页 第4页
Frowning Gaper.png Gaper.png Flaming Gaper.png Gusher.png Maggot.png Hive.png Drowned Hive.png Charger.png Hopper.png Trite.png Boil.png Gut.png Guts.png Scarred Guts.png Knight.png Selfless Knight.png
Pacer.png Horf.png Fly.png Pooter.png Drowned Charger.png Globin.png Gazing Globin.png Dank Globin.png Sack.png Spitty.png Brain.png Leaper.png Stone Grimace.png Vomit Grimace.png Poky.png Slide.png
Super Pooter.png Clotty.png Clot.png I.Blob.png Boom Fly.png Red Boom Fly.png Drowned Boom Fly.png Maw.png Mr. Maw.png Mr. Maw.png Baby.png Angelic Baby.png Dople.png Evil Twin.png Flaming Hopper.png Leech (Monster).png
Mulligan.png Mulligoon.png Mulliboom.png Attack Fly.png Red Maw.png Psychic Maw.png Host.png Red Host.png Vis.png Double Vis.png Chubber.png Scarred Double Vis.png Kamikaze Leech.png Holy Leech.png Lump.png MemBrain.png
第5页 第6页 第7页 第8页
Mama Guts.png Para-Bite.png Scarred Para-Bite.png Fred.png Buttlicker.png Hanger.png Swarmer.png Heart.png Fatty.png Pale Fatty.png Flaming Fatty.png Fat Sack.png Wall Hugger.png Wizoob.png Squirt.png Dank Squirt.png
Eye.png Bloodshot Eye (Monster).png Sucker.png Spit.png Mask.png Big Spider.png Eternal Fly.png Stone Eye.png Blubber.png Half Sack.png Death's Head.png Dank Death's Head.png Cod Worm.png Ring Fly.png Dinga.png Oob.png
Empryo.png Moter.png Spider.png Keeper.png Turret Grimace.png Brimstone Grimace.png Mobile Host.png Nest.png Mom's Hand.png Level 2 Fly.png Level 2 Spider.png Swinger.png Black Maw.png Skinny.png Rotty.png Bony.png
Gurgle.png Walking Boil.png Walking Gut.png Walking Sack.png Baby Long Legs.png Small Baby Long Legs.png Crazy Long Legs.png Small Crazy Long Legs.png Swinger.png Dip.png Corn Dip.png Corn Dip.png Homunculus.png Tumor.png Camillo Jr..png Nerve Ending.png
第9页 第10页 第11页 第12页
Nerve Ending 2.png One Tooth.png Gaping Maw.png Broken Gaping Maw.png Ticking Spider.png Begotten.png Null.png Psy Tumor.png Swarm Fly.png Mega Clotty.png Bone Knight.png Cyclopia.png Poison Mind.png Stoney.png Blister.png The Thing.png
Gurgling.png Splasher.png Grub.png Wall Creep.png Floating Knight.png Nightcrawler.png Dart Fly.png Conjoined Fatty.png Red Ghost.png Flesh Death's Head.png Mom's Dead Hand.png Dukie.png Ministro.png Portal.png
Rage Creep.png Blind Creep.png Conjoined Spitty.png Round Worm.png Blue Conjoined Fatty.png Fat Bat.png Imp.png Roundy.png Ulcer.png Meatball.png Corn Mine.png Hush Fly.png
Ragling.png Flesh Mobile Host.png Psychic Horf.png Full Fly.png Black Bony.png Black Globin.png Black Globin's Head.png Black Globin's Body.png Blue Gaper.png Blue Boil.png Greed Gaper.png Mushroom (Monster).png
第13页 第14页 第15页 第16页
Larry Jr..png The Hollow.png C.H.A.D..png Carrion Queen.png Monstro II.png Gish.png Super Sloth.png Ultra Pride.png
Monstro.png Chub.png Gurdy.png Ultra Pride Baby.png Mom.png Sloth.png Lust.png Super Lust.png
第17页 第18页 第19页 第20页
Wrath.png Super Wrath.png Greed.png Super Greed.png Pride.png Super Pride.png The Frail.png Famine.png
Gluttony.png Super Gluttony.png Envy.png Super Envy.png Pin.png Scolex.png Pestilence.png War.png
第21页 第22页 第23页 第24页
Conquest.png Death.png Peep.png The Bloat.png Fistula.png Teratoma.png It Lives.png Gemini (Boss).png
The Duke of Flies.png The Husk.png Loki.png Lokii.png Blastocyst.png Mom's Heart.png Steven (Boss).png The Blighted Ovum.png
第25页 第26页 第27页 第28页
Gemini Baby.png Steven Baby.png Krampus.png Headless Horseman.png Mask of Infamy (Mask).png Mask of Infamy (Heart).png The Wretched.png Daddy Long Legs.png
The Blighted Ovum Baby.png The Fallen.png Headless Horseman Head.png Satan.png Gurdy Jr..png Widow.png Triachnid.png Isaac (Boss).png
第29页 第30页 第31页 第32页
Blue Baby (Boss).png Gurgling.png Lil' Haunt (Boss).png Dingle.png The Gate.png Mega Fatty.png Dark One.png The Adversary.png
Turdling.png Haunt.png Dangle.png Mega Maw.png The Cage.png Mama Gurdy.png Polycephalus.png Mr. Fred.png
第33页 第34页 第35页 第36页
Uriel.png Fallen Uriel.png The Lamb.png Mega Satan's Head.png Brownie.png The Forsaken.png Ultra Greed.png Ultra Greedier.png
Gabriel.png Fallen Gabriel.png Mega Satan 2's Head.png The Stain.png Little Horn (Boss).png Rag Man.png Hush.png Rag Mega.png
第37页
Sister Vis.png Big Horn.png
Delirium.png
怪物 描述
Black Fly

Fly.png

Tiny black fly with neutral AI. Does not hurt Isaac upon touch.
Attack Fly

Attack Fly.png

Red fly that follows Isaac and deals touch damage.
Ring Fly

Ring Fly.png

Gathers with any other Ring Flies in the room. These flies orbit around themselves, while following Isaac.
DLC.png Dart Fly

Dart Fly.png

Flies towards Isaac and attempts to mimic his movements. Deals contact damage.
DLC.png Swarm Fly

Swarm Fly.png

Follows Isaac in large groups and deals contact damage.
DLC.png Hush Fly

Hush Fly.png

Gathers with other Hush Flies and flies towards Isaac in certain patterns. Can also orbit Hush.
Moter

Moter.png

Follows Isaac, similar to Attack Flies. Splits into 2 Attack Flies upon death.
Eternal Fly

Eternal Fly.png

Invulnerable fly that circles corny poop and various monsters. Turns into a vulnerable Attack Fly after the object or monster it circles is destroyed.
Pooter

Pooter.png

Slow-moving fly that occasionally fires single blood shots at Isaac. Does not deal touch damage.
Super Pooter

Super Pooter.png

An alternate version of the Pooter that fires 2 shots in a V-formation and does not deal touch damage.
Boom Fly

Boom Fly.png

Flies around the room diagonally, dealing touch damage and exploding upon death.
Red Boom Fly

Red Boom Fly.png

Flies around the room diagonally, dealing touch damage and exploding into 6 blood shots upon death.
DLC.png Drowned Boom Fly

Drowned Boom Fly.png

Flies around the room diagonally, dealing touch damage. Upon death, explodes, fires four blood shots in the cardinal directions, and spawns a Drowned Charger.
Level 2 Fly

Level 2 Fly.png

Flies toward Isaac erratically, dealing touch damage.
Full Fly

Full Fly.png

Flies toward Isaac erratically, dealing touch damage. Splits into 6 directional shots upon death.
Sucker

Sucker.png

Flies slowly towards Isaac, exploding into 4 shots in the cardinal directions upon death.
Spit

Spit.png

Flies slowly towards Isaac, firing an Ipecac shot upon death.
DLC+.png Soul Sucker

Soul Sucker.png

Flies slowly towards Isaac, firing four Brimstone beams in the cardinal directions upon death.
Dip

Fly.png

Slowly dashes in random directions, dealing contact damage.
DLC.png Corn Dip

Corn Dip.png

Quickly dashes in random directions, dealing contact damage.
Squirt

Squirt.png

Dashes towards the player and deals contact damage. Spawns 2 Dips upon death.
DLC.png Dank Squirt

Dank Squirt.png

Dashes towards the player and deals contact damage. Spawns 2 Clots upon death.
Dinga

Dinga.png

Spawns Dips and shoots brown shots in 8 directions. Spawns 2 Squirts on death.
Spider

Spider.png

Erratically moves towards Isaac and deals touch damage.
Big Spider

Big Spider.png

Erratically moves towards Isaac and deals touch damage. Splits into two Spiders upon death.
Trite

Trite.png

Quickly leaps towards Isaac and deals touch damage.
Ragling

Ragling.png

Quickly leaps towards Isaac and deals touch damage. Randomly shoots two purple shots that orbit around it.
DLC+.png Blister

Blister.png

Slowly hops towards Isaac, occasionally spawning black smoke balls. Spawns a Sack upon death.
Level 2 Spider

Level 2 Spider.png

Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances.
Ticking Spider

Ticking Spider.png

Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances. Explodes upon death.
Baby Long Legs

Baby Long Legs.png

Runs away from Isaac and frequently spawns Spiders.
Small Baby Long Legs

Small Baby Long Legs.png

Runs away from Isaac and occasionally spawns Sacks.
Crazy Long Legs

Crazy Long Legs.png

Chases Isaac, dealing touch damage. Occasionally stops to spit blood shots in 8 directions.
Small Crazy Long Legs

Small Crazy Long Legs.png

Chases Isaac, dealing touch damage. Occasionally stops to spit blood shots diagonally in 4 directions.
Wall Creep

Wall Creep.png

Crawls along walls to try to line up with Isaac and shoots three blood shots in a line.
Blind Creep

Blind Creep.png

Randomly crawls along walls and shoots three spread blood shots.
Rage Creep

Rage Creep.png

Crawls along walls to try to line up with Isaac and shoots a Brimstone laser.
DLC+.png The Thing

The Thing.png

Crawls along a wall and attempts to line up with Isaac, then spits a line of damaging red creep.
Boil

Boil.png

Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires multiple short-ranged blood projectiles in random directions when fully swollen.
Gut

Gut.png

Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires Ipecac shots in random directions when fully swollen.
Sack

Sack.png

Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Occasionally spawns Spiders when fully swollen.
DLC+.png Gush

Gush.png

Stationary, harmless enemy that continually creates slowing black creep.
DLC.png Blue Boil

Blue Boil.png

Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.
Walking Boil

Walking Boil.png

Does not shrink or regenerate. Walks around aimlessly and fires multiple short-ranged blood projectiles in random directions.
Walking Gut

Walking Gut.png

Does not shrink or regenerate. Walks around aimlessly and fires Ipecac shots in random directions.
Walking Sack

Walking Sack.png

Does not shrink or regenerate. Walks around aimlessly and occasionally spawns Spiders.
Round Worm

Round Worm.png

Pops out of the ground in random locations and spits a blood shot at Isaac if he is in sight.
Nightcrawler

Nightcrawler.png

Pops out of the ground in random locations and fires four short-range shots that spiral outwards if Isaac is in sight.
DLC+.png Tube Worm

Tube Worm.png

Pops out of the ground in random locations and fires a long-range spray of arcing shots.
DLC.png Roundy

Roundy.png

Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.
DLC.png Ulcer

Ulcer.png

Pops out of the ground in random locations and spits a blood shot at Isaac or spawns a Dart Fly if Isaac is in sight.
Mulligan

Mulligan.png

Walks around the room, avoiding Isaac. Upon death, spawns several flies, which can be Black Flies, Attack Flies, or Pooters. Can suicide to explode and launch projectiles in the four ordinal directions while still releasing flies.
Mulligoon

Mulligoon.png

Walks around the room, avoiding Isaac. Upon death, spawns a Troll Bomb and fires four shots in the ordinal directions. Can suicide to explode, spawn a Troll bomb, and launch projectiles in eight directions.
Mulliboom

Mulliboom.png

Chases Isaac and explodes upon death or upon touching Isaac. The explosion deals a half-heart of damage instead of the regular full heart.
Hive

Hive.png

Walks around the room, avoiding Isaac while spawning Attack Flies. Spawns a large number of flies upon death, which can be Black Flies, Attack Flies, Pooters, or Fat Flies.
Nest

Nest.png

Walks around the room, avoiding Isaac while spawning Spiders. Spawns a Big Spider or a Trite upon death.
DLC.png Drowned Hive

Drowned Hive.png

Walks around the room, avoiding Isaac while spawning Drowned Chargers. Spawns a Drowned Charger upon death.
Swarmer

Swarmer.png

Slowly floats around the room, spawning several Pooters upon taking damage. Spawns a Boom Fly upon death.
DLC.png Dukie

Dukie.png

Flies around the room diagonally, occasionally spitting out a Dart Fly.
Hopper

Hopper.png

Slowly hops around the room, dealing touch damage. Can turn into a Flaming Hopper by jumping into fire.
Flaming Hopper

Flaming Hopper.png

Quickly hops around the room, dealing touch damage. Covers a larger distance than the regular Hopper.
Leaper

Leaper.png

Hops around the room, dealing touch damage. Occasionally jumps high into the air, dropping down onto Isaac's position while firing 4 blood shots in the cardinal directions.
DLC+.png Ministro

Ministro.png

Hops towards Isaac, occasionally spitting out a cluster of disorganized shots.
Pacer

Pacer.png

Walks aimlessly around the room.
Gusher

Gusher.png

Walks aimlessly around the room, occasionally firing short-ranged blood shots.
DLC.png Black Globin's Body

Black Globin's Body.png

Walks aimlessly around the room, occasionally spawning spiders.
Gaper

Gaper.png

Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
Frowning Gaper

Frowning Gaper.png

Walks towards Isaac, dealing contact damage. Upon getting near Isaac, it will open its eyes and pursue Isaac faster. Usually turns into a Pacer or a Gusher upon death.
DLC.png Flaming Gaper

Flaming Gaper.png

Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
DLC.png Cyclopia

Cyclopia.png

Walks towards Isaac, dealing contact damage and leaving behind a trail of damaging red creep. Occasionally shoots a blood shot towards Isaac.
DLC.png Blue Gaper

Blue Gaper.png

Walks towards Isaac, dealing contact damage. Has triple the health of a normal Gaper.
DLC.png Greed Gaper

Greed Gaper.png

Walks towards Isaac, dealing contact damage.
Gurgle

Gurgle.png

Walks towards Isaac, firing Ipecac shots at him. Can turn into a Splasher upon death.
Splasher

Splasher.png

Walks aimlessly around the room, firing Ipecac shots in random directions.
Skinny

Skinny.png

Slowly walks towards Isaac, leaving short-lasting red creep behind itself.
Rotty

Rotty.png

Slowly walks towards Isaac, leaving short-lasting red creep behind itself. Spawns a Bony or two Attack Flies upon death.
Mr. Maw

Mr Maw.png

Walks towards Isaac and attacks by launching its head towards Isaac. Turns into a Maw or Pacer upon death depending on the killed body segment.
Horf

Horf.png

Stationary enemy that fires medium ranged blood shots at Isaac.
Psychic Horf

Psychic Horf.png

Stationary enemy that fires homing shots at Isaac.
Maw

Maw.png

Slowly floats towards Isaac, firing blood shots.
Red Maw

Red Maw.png

Floats towards Isaac and explodes into 4 blood shots in the cardinal directions upon death.
Psychic Maw

Psychic Maw.png

Slowly floats towards Isaac, firing homing shots. Spawns with an Eternal Fly orbiting around it.
Bony

Bony.png

Wanders around the room and throws a bone at Isaac when he is in sight.
DLC.png Black Bony

Black Bony.png

Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.
Death's Head

Death's Head.png

Invulnerable enemy that moves diagonally around the room, dealing contact damage. Dies when the room is cleared.
DLC.png Dank Death's Head

Dank Death's Head.png

Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.
DLC.png Flesh Death's Head

Flesh Death's Head.png

Moves diagonally around the room, dealing contact damage. Explodes into 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.
One Tooth

One Tooth.png

Follows Isaac and periodically dashes towards Isaac when it gets close. Deals contact damage.
DLC.png Fat Bat

Fat Bat.png

Slowly flies towards Isaac. Shoots when Isaac aligns diagonally with it and will actively try to avoid Isaac's shots.
Lil' Haunt

Lil' Haunt.png

Follows Isaac erratically and occasionally shoots blood shots toward Isaac's destination, predicting his movements.
Wizoob

Wizoob.png

Disappears, then appears near Isaac and spits a cluster of spectral tears at him.
DLC.png Red Ghost

Red Ghost.png

Disappears, then reappears near Isaac and fires a brimstone laser.
Fatty

Fatty.png

Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away.
DLC.png Flaming Fatty

Flaming Fatty.png

Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away. Has a chance to leave behind a damaging flame upon death.
DLC+.png Stoney

Stoney.png

Chases Isaac and blocks tears, but does not deal contact damage. Invulnerable; dies when the room is cleared.
DLC.png Conjoined Fatty

Conjoined Fatty.png

Slowly walks towards Isaac. Occasionally spits a line of damaging green creep towards Isaac. Turns into a regular Fatty upon death.
DLC.png Blue Conjoined Fatty

Blue Conjoined Fatty.png

Slowly walks towards Isaac and occasionally spits a homing Ipecac shot at Isaac.
Pale Fatty

Pale Fatty.png

Slowly walks towards Isaac. Occasionally farts and shoots blood shots in 6 directions. Can turn into a Blubber upon death.
Fat Sack

Fat Sack.png

Slowly walks towards Isaac. Occasionally leaps off-screen and attempts to land on Isaac, leaving a puddle of creep and shooting blood shots in 6 directions where it lands. Can turn into a Blubber upon death.
Blubber

Blubber.png

Walks around aimlessly and randomly spews blood around itself. Can turn into a Half Sack when killed.
Half Sack

Half Sack.png

Wanders around aimlessly and leaves a trail of red creep.
Globin

Globin.png

Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
Gazing Globin

Gazing Globin.png

Quickly chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
DLC.png Dank Globin

Dank Globin.png

Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a spider, and leaves a puddle of slowing black creep. Will regenerate after a short period of time if not killed quickly.
DLC.png Black Globin

Black Globin.png

Chases Isaac, dealing a full heart of contact damage and spawning spiders. Upon taking enough damage, it separates into a head and body. The head slides towards Isaac, leaving a trail of damaging red creep. The body wanders around aimlessly, occasionally spawning spiders.
Knight

Knight.png

Moves erratically around the room and charges toward Isaac when in line of sight. Can only be damaged from behind.
Selfless Knight

Selfless Knight.png

Moves erratically around the room and charges toward Isaac very quickly when in line of sight. Can only be damaged from behind.
Floating Knight

Floating Knight.png

Behaves like the Knight but can fly over all obstacles.
DLC.png Bone Knight

Bone Knight.png

Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a trail of damaging red creep. Can only be damaged from behind.
Mask + Heart

Mask Heart.png

The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the cardinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask.
Clotty

Clotty.png

Randomly wanders around the room, firing 4 blood shots in the cardinal directions.
Clot

Clot.png

Randomly wanders around the room, firing 4 tar shots in the ordinal directions.
I. Blob

I.Blob.png

Randomly wanders around the room, firing 8 shots in all directions.
DLC.png Mega Clotty

Mega Clotty.png

Slowly moves around the room, occasionally hopping and firing 6 blood shots in all directions. Splits into two Clotties upon death.
Mom's Hand

Mom's Hand.png

Falls from the ceiling. If it lands on Isaac, it deals damage and teleports the player back to the spawn room of the floor. Entering a room containing Mom's Hand will warn the player with Mom's laugh.
DLC.png Mom's Dead Hand

Mom's Dead Hand.png

Falls from the ceiling. If it lands on Isaac, it deals damage and teleports the player back to the spawn room of the floor. If it doesn't land on Isaac, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn the player with Mom's laugh.
Maggot

Maggot.png

Aimlessly moves around the room, dealing contact damage.
Charger

Charger.png

Slowly moves around the room, charging at Isaac when he gets in its line of sight.
DLC.png Drowned Charger

Drowned Charger.png

Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.
Spitty

Spitty.png

Slowly moves around the room, occasionally firing a single blood shot forwards.
Conjoined Spitty

Conjoined Spitty.png

Slowly moves around the room, occasionally firing blood shots from both ends of its body.
Tumor

Tumor.png

Moves around the room diagonally, occasionally firing 6 shots. Fires more often upon getting damaged.
Psy Tumor

Psy Tumor.png

Moves around the room diagonally, occasionally firing 6 homing shots. Fires more often upon getting damaged.
Camillo Jr.

Camillo Jr.png

Moves around the room diagonally, occasionally firing Technology lasers towards Isaac. Fires more often upon getting damaged.
Brain

Brain.png

Slowly crawls around the room, leaving a trail of red creep.
DLC+.png Poison Mind

Poison Mind.png

Slowly crawls around the room diagonally, leaving a trail of green creep.
MemBrain

MemBrain.png

Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Brains upon death.
Guts

Guts.png

Attaches itself to a wall or obstacle and rolls around it.
DLC.png Scarred Guts

Scarred Guts.png

Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging red creep.
Mama Guts

Mama Guts.png

Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Guts upon death.
Buttlicker

Buttlicker.png

Attaches itself to other Buttlickers and erratically moves around the room, similar to Larry Jr..
Grub

Grub.png

Erratically moves around the room like Larry Jr. and charges at Isaac when he gets within its line of sight. Spawns random types of maggots upon death, one for each of its segments.
Para-Bite

Para-Bite.png

Moves towards Isaac, dealing contact damage. Can burrow underground and reappear elsewhere.
DLC.png Scarred Para-Bite

Scarred Para-Bite.png

Moves towards Isaac, dealing contact damage and firing short-range blood shots. Can burrow underground and reappear elsewhere.
Cod Worm

Cod Worm.png

Stationary enemy that hides in a shell and spews blood if shot at. Only vulnerable when it pops its head out.
Fred

Fred.png

Hops out of the ground and burrows elsewhere, firing 4 blood shots in the ordinal directions. Occasionally fires red Ipecac shots at Isaac.
Lump

Lump.png

Fires 3 spread blood shots at Isaac when he gets in its line of sight. Will burrow underground and reappear elsewhere after firing.
DLC+.png Tar Boy

Tar Boy.png

Pops out of the ground in random locations and fires a short-ranged spray of shots that leave behind slowing black creep. If Isaac stands in the creep, the Tar Boy can fire shots straight upwards out of the creep underneath Isaac.
Leech

Leech (Monster).png

Quickly charges towards Isaac when he gets in its line of sight.
Kamikaze Leech

Kamikaze Leech.png

Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death.
Holy Leech

Holy Leech.png

Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death. Spawns with an Eternal Fly circling it.
Host

Host.png

Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will fire 3 blood shots and lower its head again.
Red Host

Red Host.png

Stationary enemy that can be damaged even when its head is lowered. Fire 5 spread blood shots when it raises its head.
Mobile Host

Mobile Host.png

Acts like the Host, but follows Isaac and deals contact damage.
Flesh Mobile Host

Flesh Mobile Host.png

Acts like the Red Host, but follows Isaac and deals contact damage.
DLC+.png Mushroom

Mushroom (Monster).png

Stationary enemy that occasionally pops up and fires four shots in the cardinal or diagonal directions. Takes less damage while its head is down.
DLC.png Meatball

Meatball.png

Slides around the room, occasionally stopping to spew a fountain of short-range blood shots in all directions or to spit a line of damaging red creep. Spawns a Host upon death.
Nerve Ending

Nerve Ending.png

Static enemy which acts as a meat shield.
DLC+.png Nerve Ending 2

Nerve Ending 2.png

Static enemy which whips at Isaac if he gets too close.
Vis

Vis.png

Charges and fires a Brimstone laser when Isaac gets in its line of sight.
Double Vis

Double Vis.png

Charges and fires a Brimstone laser which fires from both sides when Isaac gets in its line of sight.
DLC.png Scarred Double Vis

Scarred Double Vis.png

Charges and fires a Brimstone laser which fires from all four sides when Isaac gets in its line of sight.
Chubber

Chubber.png

Fires a Charger that deals one heart of damage when Isaac gets in its line of sight. The Charger is invulnerable, blocks Isaac's tears, and has limited range.
Wall Hugger

Movingspikeblock.png

Moves around the room like Guts, damaging Isaac by contact. Cannot be destroyed.
Slide

Bluespikeblock.png

Quickly slides towards Isaac when he gets in its line of sight, then moves slowly back to its original position. Cannot be destroyed.
Poky

Poky.png

Slides around the room aimlessly, damaging Isaac by contact. Disappears when the room is cleared.
Eye

Eye.png

Slowly turns towards Isaac and fires a laser at Isaac if he stands still or is too slow.
Bloodshot Eye

Bloodshot Eye (Monster).png

Slowly turns towards Isaac and fires a Brimstone beam at Isaac if he stands still or is too slow.
Dople

Dople.png

Mirrors Isaac's movements and fires blood shots at the same time as Isaac. Can be damaged by spikes.
Evil Twin

Evil Twin.png

Mirrors Isaac's movements and fires three spread blood shots at the same time as Isaac. Can fly over obstacles.
Embryo

Embryo.png

Aimlessly hops around the room, dealing contact damage.
Baby

Baby.png

Slowly floats towards Isaac and fires blood shots. Occasionally teleports and reappears elsewhere.
Angelic Baby

Angelic Baby.png

Slowly floats towards Isaac and fires three spread shots. Occasionally teleports and reappears elsewhere.
DLC.png Imp

Imp.png

Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards Isaac. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Homunculus

Homunculus.png

Starts attached to the wall. After a while, it detaches, shooting 6 blood shots and chasing Isaac. If it dies while still attached to the wall, it leaves a puddle of creep.
Begotten

Begotten.png

Starts attached to the wall. After a while, it detaches, turning the room dark and chasing Isaac. Phases in and out of visibility.
Null

Null.png

Act like faster Frowning Gapers. When Isaac gets near, they phase in and out of visibility and pursue Isaac faster.
Swinger

Swinger.png

Slowly moves towards Isaac as its head swings around its base. Upon death, spawns a Maw or a Globin depending on which part is killed.
Keeper

Keeper.png

Hops around the room, firing 2 blood shots in a V formation at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3.
Hanger

Hanger.png

Floats around the room, firing 3 spread blood shots at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3. Spawns with an eternal fly circling around it.
DLC+.png Fistuloid

Fistuloid.png

Flies towards Isaac in an erratic waving motion, periodically firing a blood shot towards Isaac that also knocks itself back. Upon death, fires a worm that flies off screen.
Stone Grimace

Stone Grimace.png

Stationary and invulnerable monster that occasionally fires blood shots at Isaac. Stops firing when room is cleared.
Vomit Grimace

Vomit Grimace.png

Stationary and invulnerable monster that occasionally fires an Ipecac shot at Isaac. Stops firing when room is cleared.
Gaping Maw

Gaping Maw.png

Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles.
Broken Gaping Maw

Broken Gaping Maw.png

Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles.
Turret Grimace

Turret Grimace.png

Stationary and invulnerable monster that continuously fires shots in a single direction.
DLC+.png Cross Grimace

Cross Grimace.png

Stationary and invulnerable monster that continuously fires shots in four directions.
Stone Eye

Stone Eye.png

Stationary and invulnerable monster that constantly rotates and fires a flickering Technology laser. Stops firing when the room is cleared.
Brimstone Grimace

Brimstone Grimace.png

Stationary and invulnerable monster that fires Brimstone beams in a specific direction.
Oob

Oob.png

When Isaac lines up with it horizontally, it charges across the room once. When Isaac is not horizontal to it, it spawns Brains.
Black Maw

Black Maw.png

When Isaac lines up with it horizontally, it charges in his direction and then doubles back, charging back to its original position. When Isaac is not horizontal to it, it spawns Kamikaze Leeches. Explodes when it dies.
DLC+.png Portal

Portal.png

Continually spawns enemies from the current floor until it is killed.

精英怪物(Champions)

Ed's basic example of potential color variations.

有些怪物有与它们在色彩及大小上略有差别的精英版本。从精英怪物的颜色可以看出它们变异的特殊能力。在普通模式中,精英怪物被杀死通常会生成掉落(根据精英怪物的颜色)。然而在困难模式中,精英怪物死亡后大概率不生成掉落。所有的精英怪物都会造成接触伤害,即便他们的普通版本没有接触伤害。大多数精英怪物会造成整颗心的伤害(无论在哪个章节)以及拥有双倍的血量。攻略困难模式,拥有冠军腰带紫色的心,或解锁成就一切都好可怕!!!后,都会增加精英怪物的出现概率。精英怪物通常比普通怪物更危险。

精英怪物的识别方法见下表:

精英类型

ID 外观 效果 掉落
0 红色 2.5倍血量。
1 黄色 增加移速及射速。 电池
2 绿色 走过的地方留下绿色水迹 药丸
3 橙色 击中角色掉落硬币(类似于贪婪)。 硬币
4 深蓝色 无。 3只蓝苍蝇
5 深绿色 死亡后爆炸。 炸弹
6 纯白色 房间内存在其他敌人时无敌。 永恒之心
7 灰色 2/3倍血量,但造成双倍伤害。 钥匙
8 透明白色 拥有幽灵眼泪,眼泪可以穿过障碍物 金宝箱
9 黑色(略带绿) 会隐身,类似于Null 红宝箱
10 粉色 定期射出短射程的血泪,类似于Gushers
11 紫色 将角色吸向自己,类似于Gaping Maw 随机饰品
12 深红色 死亡后变为一个肉块,如果没及时清理则会再生,类似于Globin 双红心
13 浅蓝色 死亡后释放8方向血泪。 半红心
14 DLC.png 保护色 拥有保护色可融入环境不易识别,只在受伤后短暂可见。 符文
15 DLC.png 闪烁绿色 死亡后生成两个普通版本的自己。 两个普通版自己
16 DLC.png 闪烁灰色 闪烁时排斥角色的子弹。
17 DLC.png 浅白色 拥有1-2个永恒苍蝇环绕。死亡后生成1只红苍蝇 红苍蝇
18 DLC.png 小体型 血量大幅降低,移速增加,音效变细。体型变小使其更难被击中。 变小药丸
19 DLC.png 大体型 血量大幅增加,移速降低,音效变粗。体型变大使其更易被击中。造成两颗心的伤害! 变大药丸
20 DLC+.png 闪烁红色 会高速给房间内的其他敌人回复血量。
21 DLC+.png 闪烁 每次攻击产生一个红苍蝇 5只蓝苍蝇
22 DLC+.png 皇冠Crown Effect.gif 血量大幅增加。房间内所有非精英怪物都会变异为它们的黄色精英版本,直到自己死亡。 2个随机掉落
23 DLC+.png 头骨 死亡时激活死灵书的效果。 死灵书效果

怪物变种(Monster Variants)

这些变种有几率取代房间内的普通怪物被生成。

重生

基础怪物 可能的替换
Mulligan.png Mulligoon.pngMulliboom.png
Hopper.png Trite.png
Stone Grimace.png Vomit Grimace.png
Dople.png Evil Twin.png
Eye.png Bloodshot Eye (Monster).png
Leech (Monster).png Kamikaze Leech.pngHoly Leech.png
Maw.png Red Maw.pngPsychic Maw.png
Host.png Red Host.png
Vis.png Double Vis.pngChubber.png
Boom Fly.png Red Boom Fly.png
Pooter.png Fat Fly.png
Pacer.png Gusher.png
Knight.png Selfless Knight.png
Clotty.pngClot.png I.Blob.png
MemBrain.png Mama Guts.png
Gaper.png Frowning Gaper.png
Globin.png Gazing Globin.png
Baby.png Angelic Baby.png
Boil.pngSack.png Gut.png
Sucker.png Spit.png

胎衣

基础怪物 可能的替换
Gaper.png Flaming Gaper.png
Fatty.png Flaming Fatty.png
Hive.png Drowned Hive.png
Charger.png Drowned Charger.png
Squirt.png Dank Squirt.png
Death's Head.png Dank Death's Head.pngFlesh Death's Head.png
Globin.png Dank Globin.png
Guts.png Scarred Guts.png
Para-Bite.png Scarred Para-Bite.png
Double Vis.png Scarred Double Vis.png

胎衣†

基础怪物 可能的替换
Keeper.pngTicking Spider.png Blister.png
Host.pngRed Host.png Mushroom (Monster).png
Hopper.pngTrite.png Ministro.png
Nerve Ending.png Nerve Ending 2.png
Brain.png Poison Mind.png
Pale Fatty.png Stoney.png
Wall Creep.pngBlind Creep.pngRage Creep.png The Thing.png
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